Despondent that the funding for his cherished limb regeneration research is to be, pardon the pun, cut off, biologist Curt Conners turns himself into a guinea pig, and finds himself transformed into the lethal Lizard! The rapacious reptile seeks refuge in the dank recesses of the New York City sewer system, pursued by our fledgling web-spinner! But unknown to them both, something far more mysterious lurks in the subterranean shadows, something known as the macabre Man-Thing!